European Journal of Anatomy

Official Journal of The Spanish Society of Anatomy
Cover Volume 8 - Number 1
Eur J Anat, 8 (1): 25-28 (2004)

The influence of procarbazine and thiocyanate on embryonic bone maturation

Weingartner J., Lieflander S., Below H., Fanghanel J., Bienengraber V.

Institute of Anatomy, Ernst Moritz Arndt Univ. Greifswald, 17487 Greifswald, Germany; Institute of Hygiene, Ernst Moritz Arndt Univ. Greifswald, 17487 Greifswald, Germany; Dept. of Cranio-Maxilo-Facial Surg., University of Rostock, 18055 Rostock, Germany; E. M. Arndt University Greifswald, Institute of Anatomy, F.- Loefffler-Str. 23c, 17487 Greifswald, Germany

ABSTRACT The substance procarbazine (NatulanĀ®) is a teratogen known to induce cleft palates in rats on day 14 post-conception. The application of thiocyanate (SCN-) alone to rats on day 10 and 14 of pregnancy had no effects on fetal bone maturation. However, when procarbazine was used, the maturation and growth of fetal bones was delayed. Upon additional application of thiocyanate, the effects of procarbazine (Natulan) were increased. Thus, no antiteratogenic effect of thiocyanate occurs. We propose that charge and metabolites of teratogenic agents play a key role in developing the effects of thiocyanate.

Keywords: procarbazine, thiocyanate, animal experiment, animal model, animal tissue, article, bone growth, bone maturation, cleft palate, controlled study, drug effect, drug efficacy, female, fetus, fetus development, fetus maturity, gestational age, metabolite, nonhuman, rat, skeleton, teratogenicity, treatment outcome

European Journal of anatomy
ISSN 2340-311X (Online)