European Journal of Anatomy

Official Journal of The Spanish Society of Anatomy
Cover Volume 5 - Number 2
Eur J Anat, 5 (2): 105-111 (2001)

The role of growth hormone in bone response for implant treatment. Experimental study using presenile animals

Clemente de Arriba C., Rodriguez-Torres R., Fernandez-Tresguerres I., Tresguerres J.A.F., Gomez-Pellico L.

Dpto. de Cie. Morfolog. y Cirugia, Facultad de Medicina, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871 Alcala de Henares, Madrid, Spain

ABSTRACT Many factors can modify osteointegration, among them the subject's age and the possibility of using hormone treatment to improve the phenomenon. In the present study we used a histological technique that permits study not only of interface, but also bone response in distant areas. Growth hormone (GH) was used topically in aged animals that had received a titanium plate as an implant in their tibiae. A similar degree of osteointegration was observed in both, the control and treated groups. Distantly located bone issue urderwent certain modifications in its osteocyte lacunae in the treated group but not in the control group.

Keywords: growth hormone, titanium, age, aged, animal cell, animal experiment, animal model, animal tissue, article, bone development, bone maturation, bone plate, bone regeneration, bone tissue, controlled study, growth hormone release, histopathology, hormone action, implant, nonhuman, osteocyte, presenile dementia

European Journal of anatomy
ISSN 2340-311X (Online)