TY  - JOUR
A1  - ,  
T1  - Abnormalities in tenectomized muscle fiber repair
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 2007
VL  - 11
SP  - 37
EP  - 45
UR  - http://www.eurjanat.com/web/paper.php?id=07010037
KW  - desmin
KW  - animal experiment
KW  - animal model
KW  - animal tissue
KW  - article
KW  - controlled study
KW  - cytoarchitecture
KW  - electron microscopy
KW  - male
KW  - microscopy
KW  - muscle fibril
KW  - muscle injury
KW  - muscle regeneration
KW  - nonhuman
KW  - rat
KW  - tendon surgery
KW  - tibialis anterior muscle
KW  - Wistar rat
N2  - Experimental tenotomy induces degenerative changes in muscle fibers, followed by an internal repair process. This study examined the cytoarchitectural changes taking place in muscle fibers due to delayed tension recovery prompted by removal of a segment of tendon. The anterior tibial muscles of Wistar rats were studied using light and electron microscopy at 4, 5 and 6 weeks after tenectomy and compared with the same muscles in controls 4 weeks after tenotomy. Control muscles displayed occasional core-like fibers. Tenectomized muscles, in addition to a larger number of core-like lesions, exhibited myofibrillar disorientation as evidenced by desmin staining and electron microscopy, which enabled identification of ring fibers, snake-coil fibers and occasional lobulated fibers. Whereas core-like lesions tended to disappear, the number of fibers displaying a myofibrillar disorientation increased with the time post-tenectomy. This suggests that extraction of a segment of tendon delays the repair of tenotomy-induced core-like lesions and gives rise to abnormal repair, leading to the formation of ring and snake-coil fibers.
ER  -