TY  - JOUR
A1  - ,  
T1  - Bone growth in IUGR rats treated with growth hormone: A multivariate approach
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 2005
VL  - 9
SP  - 149
EP  - 154
UR  - http://www.eurjanat.com/web/paper.php?id=05030149
KW  - human growth hormone
KW  - animal experiment
KW  - animal model
KW  - article
KW  - bone growth
KW  - catch up growth
KW  - controlled study
KW  - discriminant analysis
KW  - female
KW  - intrauterine growth retardation
KW  - male
KW  - morphological trait
KW  - multivariate analysis
KW  - nonhuman
KW  - principal component analysis
KW  - rat
KW  - sex difference
KW  - skeleton radiography
KW  - skull development
KW  - uterine blood vessel
KW  - weaning
N2  - The aim of this study was to assess the morphological changes (in size and shape) in Intrauterine Growth Retarded (IUGR) rats treated with growth hormone. Wistar albino rats were divided into the following groups: Control, Sham-operated, Intrauterine growth retarded, and Intrauterine growth retarded injected with growth hormone. Intrauterine growth retardation was induced by partial bending of uterine vessels on day 14 of pregnancy. After weaning, all groups received a stock diet ad libitum. At 84 days of age, the animals were X-rayed on the dorsal and lateral planes. Cranial and postcranial measurements were taken on each radiograph. Data were standardized and processed by principal component and discriminant analysis. Both the first component and discriminant function revealed size differences between sexes and treatments. Males were larger than females. Sham males were the largest, followed by intrauterine growth retarded animals treated with growth hormone and intrauterine growth retarded rats. Sham and intrauterine growth retarded females treated with growth hormone were similar and larger than their IUGR counterparts. The second and subsequent components and discriminant functions described shape variations. Sham and intrauterine growth retarded animals treated with growth hormone formed a single cluster separated from intrauterine growth retarded rats. Intrauterine growth retardation produces a differential reduction of bone dimensions, i.e. a modification of allometric growth. Growth hormone seems to promote harmonic growth recovery (size and shape) only in females.
ER  -