TY - JOUR A1 - , T1 - Noise-induced duodenal lesions JO - Eur. J. Anat. SN - 1136-4890 Y1 - 2005 VL - 9 SP - 29 EP - 33 UR - http://www.eurjanat.com/web/paper.php?id=05010029 KW - animal experiment KW - animal model KW - animal tissue KW - article KW - cell death KW - cell degeneration KW - controlled study KW - duodenum disease KW - duodenum erosion KW - duodenum ulcer KW - dyspepsia KW - erosion KW - evaluation KW - experimental model KW - histopathology KW - intestine brush border KW - low frequency noise KW - microscopy KW - noise injury KW - nonhuman KW - rat KW - rat strain KW - scanning electron microscopy KW - symptom KW - vibroacoustic disease KW - whole body vibration N2 - Vibroacoustic disease (VAD) is a systemic disease that results from long-term exposure to low-frequency noise (LFN). VAD can cause lesions in several organs. Noise-exposed individuals frequently present digestive symptoms, but only a few studies have attempted to evaluate gastrointestinal lesions. The aim of this study was to investigate the duodenal alterations in VAD, using an animal model of the disease. Adult Wistar rats were exposed to continuous LFN. After five, nine and thirteen weeks they were sacrificed. The duodenums were studied by light microscopy and scanning electron microscopy, and compared with those of animals kept in silence. Superficial erosions and wide-spread cell death with microvilli coalescence and fusion were observed, by light and electron microscopy. Erosion, cellular degeneration and death, and microvilli destruction, reflect noise-induced duodenal alterations in rats which may be equivalent to the ulcers and dyspeptic symptoms reported in human VAD patients. ER -