TY  - JOUR
A1  - ,  
T1  - The osteoinductive potential of MTA (Mineral Trioxide Aggregate): A histologic study in rabbits
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 2004
VL  - 8
SP  - 101
EP  - 105
UR  - http://www.eurjanat.com/web/paper.php?id=04030101
KW  - biomaterial
KW  - eosin
KW  - hematoxylin
KW  - mineral
KW  - mineral trioxide aggregate
KW  - oxide
KW  - unclassified drug
KW  - adolescent
KW  - animal experiment
KW  - animal tissue
KW  - article
KW  - biocompatibility
KW  - bone defect
KW  - bone growth
KW  - bone regeneration
KW  - controlled study
KW  - Goldner Trichome staining
KW  - growth rate and growth regulation
KW  - histology
KW  - implant
KW  - inflammation
KW  - male
KW  - mandible
KW  - microscopy
KW  - nonhuman
KW  - oral surgery
KW  - ossification
KW  - rabbit
KW  - staining
N2  - The objective of this study was to investigate bone response after implantation of MTA (Mineral Trioxide Aggregate) in the rabbit mandible. Experiments were carried out on the right mandibular body of 8 adult male rabbits. The animals were divided into two groups (control group and test group). In this in vivo study, MTA was used as an interpositional graft material in critical-size bone defects of rabbit mandibles. The animals were sacrificed on day 30 after surgery. The samples obtained from the mandibles were subjected to histological procedures, which permitted the collection of sections with a thickness of 60±10?m. The sections were stained with Haematoxylin and Eosin and Goldner Trichrome stain and examined under a light microscope. No important inflammatory reactions were detected in any of the samples of the treated group. The results confirm the excellent biocompatibility of MTA. The implantation of MTA in bone defects led to bone regeneration 4 weeks after surgery. However, the growth rate was not significant and the amount of newly formed bone was limited with the use of MTA in this specific application. Sample examination did not suggest complete evidence of new bone growth from either an inductive or conductive perspective.
ER  -