TY  - JOUR
A1  - ,  
T1  - The influence of procarbazine and thiocyanate on embryonic bone maturation
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 2004
VL  - 8
SP  - 25
EP  - 28
UR  - http://www.eurjanat.com/web/paper.php?id=04010025
KW  - procarbazine
KW  - thiocyanate
KW  - animal experiment
KW  - animal model
KW  - animal tissue
KW  - article
KW  - bone growth
KW  - bone maturation
KW  - cleft palate
KW  - controlled study
KW  - drug effect
KW  - drug efficacy
KW  - female
KW  - fetus
KW  - fetus development
KW  - fetus maturity
KW  - gestational age
KW  - metabolite
KW  - nonhuman
KW  - rat
KW  - skeleton
KW  - teratogenicity
KW  - treatment outcome
N2  - The substance procarbazine (Natulan®) is a teratogen known to induce cleft palates in rats on day 14 post-conception. The application of thiocyanate (SCN-) alone to rats on day 10 and 14 of pregnancy had no effects on fetal bone maturation. However, when procarbazine was used, the maturation and growth of fetal bones was delayed. Upon additional application of thiocyanate, the effects of procarbazine (Natulan) were increased. Thus, no antiteratogenic effect of thiocyanate occurs. We propose that charge and metabolites of teratogenic agents play a key role in developing the effects of thiocyanate.
ER  -